Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia

@article{Dmitrieva2009SemaxAP,
  title={Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia},
  author={Veronika G. Dmitrieva and Oksana V. Povarova and Veronika I. Skvortsova and Svetlana A Limborska and Nikolai Fedorovich Myasoedov and Lyudmila V Dergunova},
  journal={Cellular and Molecular Neurobiology},
  year={2009},
  volume={30},
  pages={71-79}
}
Consisting of a fragment of ACTH(4–7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. Previous experiments showed rapid induction of Bdnf, Ngf, and TrkB expression in intact rat hippocampus following Semax treatment. To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO). We… CONTINUE READING

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