Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents

@article{Eremin2005SemaxAA,
  title={Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents},
  author={K. O. Eremin and V. S. Kudrin and Pirjo Saransaari and S. S. Oja and Igor A. Grivennikov and Nikolay F. Myasoedov and Kirill S. Rayevsky},
  journal={Neurochemical Research},
  year={2005},
  volume={30},
  pages={1493-1500}
}
Corticotrophin (ACTH) and its analogues, particularly Semax (Met-Glu-His-Phe-Pro-Gly-Pro), demonstrate nootropic activity. Close functional and anatomical links have been established between melanocortinergic and monoaminergic brain systems. The aim of present work was to investigate the effects of Semax on neurochemical parameters of dopaminergic- and serotonergic systems in rodents. The tissue content of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum was significantly increased (+25%) 2… 
Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action
TLDR
Semax normalized the animal behavior disturbed by the CCK-4 administration, which attests to its anxiolytic and antidepressant effects at elevated levels of anxiety and depression.
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats
TLDR
The neuroprotective action of Semax may be associated with a compensation of mRNA expression patterns that are disrupted during ischaemia–reperfusion conditions, as identified in the brains of rats at 24 h after being treated with Semax relative to saline.
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion
TLDR
The suppression of inflammatory and cell death processes and the activation of recovery may contribute to the neuroprotective action of Semax at both the transcriptome and protein levels.
Expression changes caused by the peptide semax in the intracellular signal pathway genes in rat hippocamp
TLDR
The teams from the Institute of Molecular Genetics and Moscow State University created the peptide Met–Glu– His–Phe–Pro–Gly–Pro, which was named semax, which has been shown that semax enhances the survival of brain cells during hypoxia and increases the selective attention and memory trace consolidation.
Comparison of the Temporary Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina Under Semax Action
TLDR
It was revealed that after Semax administration the multidirectional activation of the expression of the genes under investigation in the hippocampus, frontal cortex, and retina was observed and both neurotrophin genes was decreased in rat hippocampus and retina 20 min afterSemax administration.
Investigation of the effect of a modified fragment of neuropeptide Y on memory phases and extrapolation escape of animals.
TLDR
Peptide NP9 demonstrated the ability to improve memorization due to its effect on I phase of memory and facilitated extinction of negative experiences when administered after a stress stimulus and increased the cognitive ability of animals in the conditions an aversive environment in the extrapolation escape test.
Time course of the expression of genes of brain-derived neurotrophic factor and nerve growth factor in the hippocampus and frontal cortex induced by semax in rats
TLDR
An analysis of the time course of the expression of NGF and BDNF genes in the hippocampus and frontal cortex in rats after a single intranasal administration of semax found that semax administration resulted in a rapid long-term activation of the N GF andBDNF genes expression, which was specific for different rat brain structures investigated.
Synthetic Peptides Affect the Expression of Gdnf and Gdnf Receptors in Rats with 6-OHDA-Induced PD-Like Parkinsonism
TLDR
Findings suggest that DNSP-5 and SD have potential neuroprotective properties and may stimulate the surviving DA neurons in Parkinson's disease.
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References

SHOWING 1-10 OF 42 REFERENCES
The Heptapeptide SEMAX stimulates BDNF Expression in Different Areas of the Rat Brain in vivo
TLDR
The heptapeptide SEMAX is an analog of the ACTH(4–10) fragment completely devoid of any hormonal activity present in the full-length ACTH molecule and produces a marked nootropic effect if administered at very small doses.
Effect of Sulpiride on the Amphetamine-Induced Changes in Extracellular Dopamine, DOPAC, and Hydroxyl Radical Generation in the Rat Striatum
TLDR
The dopamine receptor antagonist sulpiride proved able to prevent the delayed loss of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) and depressed the gradual generation of hydroxyl radicals induced in the rat striatum by D-amphetamine.
Melanocortins and the brain: from effects via receptors to drug targets.
Characterization of the inhibitory effect of adrenocorticotropin/melanocyte-stimulating hormone-like peptides on the binding of dopamine receptor ligands to the dopamine D2 receptor in vitro.
TLDR
In both young and old rats, whose membranes are reported to differ in lipid composition and membrane fluidity, ACTH-(1-24) inhibited the binding of [3H]NPA to the dopamine D2 receptor to nearly the same extent, suggesting a G-protein-independent mechanism of action.
Entry of the synthetic ACTH(4–10) analogue into the rat brain following intravenous injection
[A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study)].
TLDR
It has been demonstrated that this peptide is capable to stimulate operative memory and attention, to increase resistance to hypoxia and to improve brain circulation in experimental animals and human beings over prolonged period.
Correlation between structure, behavioral activity and rate of biotransformation of some ACTH4-9 analogs.
TLDR
The increase in behavioral potency as a result of amino acid substitutions can be explained, at least partly, by increased resistance against biotransformation.
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