Semaphorin3A-induced receptor endocytosis during axon guidance responses is mediated by L1 CAM

@article{Castellani2004Semaphorin3AinducedRE,
  title={Semaphorin3A-induced receptor endocytosis during axon guidance responses is mediated by L1 CAM},
  author={Valerie Castellani and Julien Falk and Genevi{\`e}ve N. Rougon},
  journal={Molecular and Cellular Neuroscience},
  year={2004},
  volume={26},
  pages={89-100}
}
During axon navigation, Semaphorin3A-induced growth cone retraction is correlated with endocytosis. Although its function remains elusive, we showed previously that the cell adhesion molecule of the immunoglobulin super family L1 associates with Neuropilin-1 (NP-1) the Sema3A-binding subunit of the receptor complex and is required for Sema3A to elicit axonal repulsive responses. We report here that upon Sema3A binding to NP-1, L1 and NP-1 are co-internalized through a clathrin-dependent… CONTINUE READING
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