Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin.

@article{Capparuccia2009SemaphorinSI,
  title={Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin.},
  author={Lorena Capparuccia and Luca Tamagnone},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 11},
  pages={1723-36}
}
Semaphorins are a large family of secreted and membrane-bound molecules that were initially implicated in the development of the nervous system and in axon guidance. More recently, they have been found to regulate cell adhesion and motility, angiogenesis, immune responses, and tumor progression. Semaphorin receptors, the neuropilins and the plexins, are expressed by a wide variety of cell types, including endothelial cells, bone-marrow-derived cells and cancer cells. Interestingly, a growing… CONTINUE READING
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