Semaphorin Signaling in Cancer-Associated Inflammation

@inproceedings{Franzolin2019SemaphorinSI,
  title={Semaphorin Signaling in Cancer-Associated Inflammation},
  author={Giulia Franzolin and Luca Tamagnone},
  booktitle={International journal of molecular sciences},
  year={2019}
}
The inflammatory and immune response elicited by the growth of cancer cells is a major element conditioning the tumor microenvironment, impinging on disease progression and patients' prognosis. Semaphorin receptors are widely expressed in inflammatory cells, and their ligands are provided by tumor cells, featuring an intense signaling cross-talk at local and systemic levels. Moreover, diverse semaphorins control both cells of the innate and the antigen-specific immunity. Notably, semaphorin… CONTINUE READING

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