Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.

@article{Segarra2012Semaphorin6R,
  title={Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.},
  author={M. Dolores Segarra and Hidetaka Ohnuki and Dragan Maric and Ombretta Salvucci and Xu Wei Hou and Anil Kumar and Xuri Li and Giovanna Tosato},
  journal={Blood},
  year={2012},
  volume={120 19},
  pages={4104-15}
}
Formation of new vessels during development and in the mature mammal generally proceeds through angiogenesis. Although a variety of molecules and signaling pathways are known to underlie endothelial cell sprouting and remodeling during angiogenesis, many aspects of this complex process remain unexplained. Here we show that the transmembrane semaphorin6A (Sema6A) is expressed in endothelial cells, and regulates endothelial cell survival and growth by modulating the expression and signaling of… CONTINUE READING
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