Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells

Abstract

Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates dendritic spine density in a cell… (More)
DOI: 10.7554/eLife.04390

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@inproceedings{Duan2014Semaphorin5I, title={Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells}, author={Yuntao Duan and Shih-Hsiu J Wang and Juan Song and Yevgeniya A. Mironova and Guo-Li Ming and Alex L Kolodkin and Roman J Giger}, booktitle={eLife}, year={2014} }