Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells

@inproceedings{Duan2014Semaphorin5I,
  title={Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells},
  author={Yuntao Duan and S. Wang and Juan Song and Yevgeniya A. Mironova and Guoli Ming and Alex L Kolodkin and Roman J Giger},
  booktitle={eLife},
  year={2014}
}
Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates dendritic spine density in a cell… CONTINUE READING
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