Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

  title={Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis},
  author={Masayuki Nishide and Satoshi Nojima and Daisuke Ito and Hyota Takamatsu and Shohei Koyama and Sujin Kang and Tetsuya Kimura and Keiko Morimoto and Takashi Hosokawa and Yoshitomo Hayama and Yuhei Kinehara and Yasuhiro Kato and Takeshi Nakatani and Yoshimitsu Nakanishi and Takeshi Tsuda and JeongHoon Park and Toru Hirano and Yoshihito Shima and Masashi Narazaki and Eiichi Morii and Atsushi Kumanogoh},
  journal={Annals of the Rheumatic Diseases},
  pages={1440 - 1448}
Objectives Inappropriate activation of neutrophils plays a pathological role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The aim of this study was to investigate the functions of semaphorin 4D (SEMA4D) in regulation of neutrophil activation, and its involvement in AAV pathogenesis. Methods Serum levels of soluble SEMA4D were evaluated by ELISA. Blood cell-surface expression of membrane SEMA4D was evaluated by flow cytometry. To determine the functional… 

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