Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.

  title={Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.},
  author={Ying-Hua Yang and Asma Buhamrah and Abraham Schneider and Yi-Ling Lin and Hua Zhou and Amr Bugshan and John R. Basile},
  journal={PloS one},
  volume={11 2},
Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for axon guidance, are now known to play a role in this process as well. Emerging data have identified Semaphorin 4D (Sema4D) as a product of osteoclasts acting through its receptor Plexin-B1 on osteoblasts to inhibit their function, tipping the… CONTINUE READING