Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.

  title={Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.},
  author={Viola Maier and Christine Jolicoeur and Helen Rayburn and Noriko Takegahara and Atsushi Kumanogoh and Hitoshi Kikutani and Marc Tessier-Lavigne and Wolfgang Wurst and Roland H Friedel},
  journal={Molecular and cellular neurosciences},
  volume={46 2},
Semaphorins and Plexins are cognate ligand-receptor families that regulate important steps during nervous system development. The Plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development, however, its specific ligands have only been suggested by in vitro studies. Here, we show by in vivo and in vitro analyses that the two Semaphorin-4 family members Sema4C and Sema4G are likely to be in vivo ligands of Plexin-B2. The Sema4C and Sema4G genes are… CONTINUE READING


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