Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish.

@article{Sakai2006Semaphorin3G,
  title={Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish.},
  author={Jill A Sakai and Mary C. Halloran},
  journal={Development},
  year={2006},
  volume={133 6},
  pages={1035-44}
}
The optic chiasm is an important choice point at which retinal ganglion cell (RGC) axons either cross the midline to innervate the contralateral brain or turn back to innervate the ipsilateral brain. Guidance cues that regulate this decision, particularly those directing the midline crossing of contralateral axons, are still not well understood. Here we show that Sema3d, a secreted semaphorin expressed at the midline, guides the crossing of RGC axons in zebrafish. Both Sema3d knockdown and… CONTINUE READING

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