Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.


UNLABELLED Peri-prosthetic osteolysis (PPO) occurs in response to prosthetic wear particles causing an inflammatory reaction in the surrounding tissue that leads to subsequent bone loss. Semaphorin-3a (SEM3A), neuropilin-1 (NRP1) and plexin-A1 (PLEXA1) are axonal guidance molecules that have been recently implicated in regulating bone metabolism. This study… (More)
DOI: 10.1016/j.actbio.2015.11.025


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