Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.

@article{Gu2005Semaphorin3A,
  title={Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.},
  author={Chenghua Gu and Yutaka Yoshida and Jean Livet and Dorothy V. Reimert and Fanny Mann and Janna Merte and Christopher E Henderson and Thomas M. Jessell and Alex L Kolodkin and David D Ginty},
  journal={Science},
  year={2005},
  volume={307 5707},
  pages={
          265-8
        }
}
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent intersomitic vessels. Sema3E-plexin-D1 signaling did not require neuropilins, which were previously… CONTINUE READING
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