Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism.

@article{Kim2011Semaphorin3S,
  title={Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism.},
  author={Jiha Kim and Won-Jong Oh and Nicholas R Gaiano and Yutaka Yoshida and Chenghua Gu},
  journal={Genes & development},
  year={2011},
  volume={25 13},
  pages={1399-411}
}
Blood vessel networks are typically formed by angiogenesis, a process in which new vessels form by sprouting of endothelial cells from pre-existing vessels. This process is initiated by vascular endothelial growth factor (VEGF)-mediated tip cell selection and subsequent angiogenic sprouting. Surprisingly, we found that VEGF directly controls the expression of Plexin-D1, the receptor for the traditional repulsive axon guidance cue, semaphorin 3E (Sema3E). Sema3E-Plexin-D1 signaling then… CONTINUE READING
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