Semaphorin 3A is a chemoattractant for cortical apical dendrites

@article{Polleux2000Semaphorin3I,
  title={Semaphorin 3A is a chemoattractant for cortical apical dendrites},
  author={F. Polleux and T. Morrow and Anirvan Ghosh},
  journal={Nature},
  year={2000},
  volume={404},
  pages={567-573}
}
The apical dendrites of pyramidal neurons integrate inputs from various cortical layers and are central to information processing. Here we show that the growth of apical dendrites towards the pial surface is regulated by a diffusible chemoattractant present at high levels near the marginal zone. A major component of this signal is semaphorin 3A (Sema3A), which was previously characterized as a chemorepellant for cortical axons. Soluble guanylate cyclase is asymmetrically localized to the… Expand
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