Semaphorin-1a Controls Receptor Neuron-Specific Axonal Convergence in the Primary Olfactory Center of Drosophila

@article{Lattemann2007Semaphorin1aCR,
  title={Semaphorin-1a Controls Receptor Neuron-Specific Axonal Convergence in the Primary Olfactory Center of Drosophila},
  author={Marc Lattemann and Ariane Zierau and Claus J. Schulte and Sascha Seidl and Britta Kuhlmann and Thomas Hummel},
  journal={Neuron},
  year={2007},
  volume={53},
  pages={169-184}
}
In the olfactory system of Drosophila, 50 functional classes of sensory receptor neurons (ORNs) project in a highly organized fashion into the CNS, where they sort out from one another and converge into distinct synaptic glomeruli. We identified the transmembrane molecule Semaphorin-1a (Sema-1a) as an essential component to ensure glomerulus-specific axon segregation. Removal of sema-1a in ORNs does not affect the pathfinding toward their target area but disrupts local axonal convergence into a… CONTINUE READING

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