Semantic knowledge in patient H.M. and other patients with bilateral medial and lateral temporal lobe lesions

@article{Schmolck2002SemanticKI,
  title={Semantic knowledge in patient H.M. and other patients with bilateral medial and lateral temporal lobe lesions},
  author={Heike Schmolck and Elizabeth A. Kensinger and Suzanne Corkin and Larry R. Squire},
  journal={Hippocampus},
  year={2002},
  volume={12}
}
We investigated the effects of damage to the medial temporal lobe (MTL) and anterolateral temporal cortex on semantic knowledge. We studied eight male controls, two patients with lesions limited to the hippocampal formation, three postencephalitic patients with extensive MTL lesions and variable damage to the lateral temporal cortex, and patient H.M. (whose lesion is limited mostly to the MTL, but who also has minimal damage to the anterolateral cortex). On 13 tests of semantic memory, patients… 
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  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
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References

SHOWING 1-10 OF 68 REFERENCES
Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation
TLDR
The present results substantiate the idea that severity of memory impairment is dependent on locus and extent of damage within the hippocampal formation and that damage to the hippocampusal formation can cause temporally graded retrograde amnesia.
H. M.’s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging
TLDR
The view that lesions of the hippocampal formation and adjacent cortical structures can produce global and enduring amnesia and can exacerbate amnesia beyond that seen after more selective hippocampal lesions is reinforced.
Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient H.M.
TLDR
It is concluded that medial temporal lobe structures are not critical for retention and use of already acquired lexical information or for grammatical processing, but they are required for acquisition ofLexical information, as evidenced in previous studies revealing H.M.'s profound impairment at learning new words.
Memory, Language, and Neuroanatomy: A Reply
TLDR
The interpretation is that the hippocampal formation is not essential for understanding ambiguity and that memory impairment can occur in isolation from an impairment in understanding ambiguity.
Retrograde Amnesia for Facts and Events: Findings from Four New Cases
TLDR
Tests of anterograde and retrograde memory function suggest that whether retrograde amnesia is temporally limited or very extensive depends on whether the damage is restricted to the hippocampal formation or also involves additional temporal cortex.
Detection and explanation of sentence ambiguity are unaffected by hippocampal lesions but are impaired by larger temporal lobe lesions
TLDR
The ability to comprehend ambiguity is independent of the hippocampal formation and three patients with larger temporal lobe lesions, which extended beyond the medial temporal lobe, were impaired to about the same degree as the noted amnesic patient H.M.
Intact Perceptual Priming in a Patient with Damage to the Anterior Inferior Temporal Lobes
TLDR
The results suggest that the anterior IT is not involved in the storage of pre-existing structural descriptions of known objects, the ability to create new structural descriptions for novel objects, and the able to compute descriptions that are invariant with respect to changes in size and reflection.
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
TLDR
The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
A neural basis for the retrieval of conceptual knowledge
Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia
TLDR
Hippocampal atrophy is not specific for AD but is also seen in semantic dementia, and these findings have implications for diagnosis and understanding of the cognitive deficits in AD and semantic dementia.
...
...