Sema4A induces cell morphological changes through B-type plexin-mediated signaling.

  title={Sema4A induces cell morphological changes through B-type plexin-mediated signaling.},
  author={Kazunori Yukawa and Tetsuji Tanaka and Kenji Yoshida and Noriko Takeuchi and Takuji Ito and Hyota Takamatsu and Hitoshi Kikutani and Atsushi Kumanogoh},
  journal={International journal of molecular medicine},
  volume={25 2},
Semaphorins are a family of secreted and membrane-bound proteins known as axonal pathfinders. Sema4A, a member of class 4 semaphorins, induces growth cone collapse of hippocampal neurons. The binding of Sema4A to growth cones indicates the presence of receptors transmitting signals through the intracellular effectors to induce growth cone collapse in hippocampal neurons. Transfection experiments of the candidate receptor genes into COS-7 cells demonstrated that Sema4A binds to axonal guidance… CONTINUE READING
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