Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1

  title={Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1},
  author={M. J. Hamm and B. Kirchmaier and W. Herzog},
  journal={The Journal of Cell Biology},
  pages={415 - 430}
  • M. J. Hamm, B. Kirchmaier, W. Herzog
  • Published 2016
  • Medicine, Biology
  • The Journal of Cell Biology
  • Semaphorins regulate guidance during cell migration. In addition to repelling endothelial cells, Hamm et al. identify a novel mechanism by which Semaphorin3d/Neuropilin1 regulates collective endothelial cell migration through activating a kinase cascade, which regulates Actin network organization and cell–cell contacts. 
    GIPC proteins negatively modulate Plexind1 signaling during vascular development
    • 3
    • Highly Influenced
    • Open Access
    Guidance Molecules in Vascular Smooth Muscle
    • 7
    • Open Access


    Publications referenced by this paper.
    Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
    • 455
    Semaphorin 3d and Semaphorin 3e Direct Endothelial Motility through Distinct Molecular Signaling Pathways*
    • 39
    • Highly Influential
    • Open Access
    Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
    • 541
    Rho GTPases and their role in organizing the actin cytoskeleton
    • 323
    • Open Access
    Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis
    • 64
    • Highly Influential
    • Open Access
    NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells
    • 56
    • Highly Influential
    • Open Access
    The role of semaphorins and their receptors in vascular development and cancer.
    • 94
    • Highly Influential
    • Open Access
    Collective cell migration in morphogenesis, regeneration and cancer
    • 1,789
    • Open Access