Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1

@inproceedings{Hamm2016Sema3dCC,
  title={Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1},
  author={Mailin Julia Hamm and Bettina Carmen Kirchmaier and Wiebke Herzog},
  booktitle={The Journal of cell biology},
  year={2016}
}
During cardiovascular development, tight spatiotemporal regulation of molecular cues is essential for controlling endothelial cell (EC) migration. Secreted class III Semaphorins play an important role in guidance of neuronal cell migration and were lately linked to regulating cardiovascular development. Recently, SEMA3D gene disruptions were associated with cardiovascular defects in patients; however, the mechanisms of action were not revealed. Here we show for the first time that Sema3d… CONTINUE READING
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