Sema 4D/CD100-plexin B is a multifunctional counter-receptor

  title={Sema 4D/CD100-plexin B is a multifunctional counter-receptor},
  author={Yusi Zhang and Bei Liu and Yingjiang Ma and Boquan Jin},
  journal={Cellular and Molecular Immunology},
T he discovery of Sema 4D can be dated to 1992, when Boumsell’s team reported a novel 150-kDa glycoprotein dimer. It was expressed on T lymphocytes that had been activated with CD3 monoclonal antibody or phytohaemagglutinin. Hence, this molecule has been designated CD100 by the International Workshop on Human Leukocyte Differentiation Antigen. In 1996, 3 years after the discovery of the semaphorin family, the CD100 gene was cloned and identified as the first semaphorin with immune system… CONTINUE READING


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