Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist.

@article{Davis2000SelfotelIA,
  title={Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist.},
  author={Stephen M Davis and Kennedy R. Lees and Gregory W. Albers and Hans Christoph Diener and Sabri Markabi and Goeril Karlsson and John Norris},
  journal={Stroke},
  year={2000},
  volume={31 2},
  pages={347-54}
}
BACKGROUND AND PURPOSE Based on neuroprotective efficacy in animal models, we evaluated the N-methyl D-aspartate antagonist Selfotel in patients with ischemic stroke, after doses up to 1.5 mg/kg were shown to be safe in phase 1 and phase 2a studies. METHODS Two pivotal phase 3 ischemic stroke trials tested the hypothesis, by double-blind, randomized, placebo-controlled parallel design, that a single intravenous 1.5 mg/kg dose of Selfotel, administered within 6 hours of stroke onset, would… CONTINUE READING