Selfish operons: horizontal transfer may drive the evolution of gene clusters.

@article{Lawrence1996SelfishOH,
  title={Selfish operons: horizontal transfer may drive the evolution of gene clusters.},
  author={Jeffrey G. Lawrence and John R. Roth},
  journal={Genetics},
  year={1996},
  volume={143 4},
  pages={
          1843-60
        }
}
A model is presented whereby the formation of gene clusters in bacteria is mediated by transfer of DNA within and among taxa. Bacterial operons are typically composed of genes whose products contribute to a single function. If this function is subject to weak selection or to long periods with no selection, the contributing genes may accumulate mutations and be lost by genetic drift. From a cell's perspective, once several genes are lost, the function can be restored only if all missing genes… 

Figures and Tables from this paper

Conditions for the Evolution of Gene Clusters in Bacterial Genomes
TLDR
The computational analysis here has shown that the evolution of gene clusters can occur under both direct and indirect selection as long as certain conditions hold, and that the selfish operon model is still viable as an explanation for the evolutionof gene clusters.
Evolution of mosaic operons by horizontal gene transfer and gene displacement in situ
TLDR
The discovery of in situ gene displacement shows that combination of rampant horizontal gene transfer with selection for preservation of operon structure provides for events in prokaryotic evolution that, a priori, seem improbable.
Supra-operonic clusters of functionally related genes (SOCs) are a source of horizontal gene co-transfers
TLDR
It is proposed that SOCs form a basic unit of horizontal gene transfer, a model based on the co-transfer of genes within operons that is highly consistent with the size distribution of supra-operonic clusters (SOCs), groups of co-occurring and co-functioning genes that extend beyond operons.
Lateral Gene Transfer in Operons and Its Effects on Neighbouring Genes
TLDR
The results indicate that there is evidence for integration of functionally annotated genes into operons by homologous recombination, and LGT causes an increase in the rate of evolution of genes that are n eighbours of laterally transferred genes.
Impact of Horizontal Genetic Transfer on the Evolution of Bacterial Genomes
TLDR
If the roles of horizontal genetic transfer and chromosomal deletion are considered in shaping the composition of bacterial chromosomes, it can be seen that the mode of genome evolution has strong implications for how bacteria diversify.
Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia coli
TLDR
The histories of regulatory interactions from the model bacterium Escherichia coli K12 found that the evolution of regulation by duplication was rare, and surprisingly, many of the regulatory interactions that are shared between paralogs result from convergent evolution.
Selection for gene clustering by tandem duplication.
TLDR
Evidence is presented that the tandem duplication of related genes acts as a driving evolutionary force in the origin and maintenance of clusters, and the possibility is raised that tandem gene duplication works in concert with horizontal gene transfer as interrelated evolutionary forces for gene clustering.
Operon formation is driven by co-regulation and not by horizontal gene transfer.
TLDR
It is proposed that new operons reduce the amount of regulatory information required to specify optimal expression patterns and infer that operons should be more likely to evolve than independent promoters when regulation is complex, and operons have greater amounts of conserved regulatory sequences than do individually transcribed genes.
Gene Transfer in Escherichia coli
TLDR
The possibility of major recent changes in the rates of intraspecific gene transfer in E. coli seems contradicted by the presence of clonal segments.
...
...

References

SHOWING 1-10 OF 118 REFERENCES
The evolution of gene clusters and genetic circularity in microorganisms.
TLDR
The clustering of genes controlling the same character provides prima facie evidence of an orthotopic linkage system.
Lateral transfer in natural populations of eukaryotes.
TLDR
The importance of lateral transfers for host organisms must await answers to more general questions about the long-term evolutionary significance of mobile elements and the extent to which they can act as vectors for host genomic sequences.
Fine structure mapping by complete transduction between histidine-requiring Salmonella mutants.
TLDR
The growth characteristics, accumulations and genetic tests carried out by means of complete transduction for over 200 independently isolated histidine-requiring (his) mutants of Salmonella typhimurium are described, consistent with the view that processes involved in intra- and inter-genic recombination are identical.
A THEORY OF MODULAR EVOLUTION FOR BACTERIOPHAGES *
  • D. Botstein
  • Biology
    Annals of the New York Academy of Sciences
  • 1980
The modular theory of virus evolution has clear experimental support among the temperate bacteriophages of the enteric bacteria. However, there is also similar genetic and DNA heteroduplex evidence
Periodic selection, infectious gene exchange and the genetic structure of E. coli populations.
TLDR
It is postulated that E. coli is composed of a relatively limited number of geographically widespread and genetically nearly isolated and monomorphic lineages, and the implications of these considerations of the genetic structure of E. bacteria populations on the interpretation of protein variation and the neutral gene hypothesis are discussed.
A case of neighboring loci with similar effects.
TLDR
The question has seldom been asked “what meaning is to be attached to such mimic or duplicate genes when they are very near to each other in the chromosome and when their effects are not identical but only very similar?” but such questions present themselves when actual cases of this sort are found, and even though such cases are rare, they suggest hypotheses which call into account.
...
...