196 Citations
A novel intron site in the triosephosphate isomerase gene from the mosquito Culex tarsalis
- BiologyNature
- 1993
The TPI gene from the mosquito, Culex tarsalis, contains an intron in a unique position that was predicted by W. Gilbert2 and the exon shuffling hypothesis, and is found to be consistent with the 'introns late' view.
The Origin and Function of Intervening Sequences in DNA: A Review
- BiologyThe American Naturalist
- 1987
Current data support the second view, suggesting that although introns have played an important role in the evolution of new functional proteins, this role cannot be seen as an adaptation, at least at the level of organisms within a species.
Human Transaldolase-associated Repetitive Elements Are Transcribed by RNA Polymerase III*
- BiologyThe Journal of Biological Chemistry
- 2000
The results suggest RNA polymerase III-mediated transcription of TARE may be a source of repetitive elements, contributing to distinct genes and thus shaping the human genome.
Reverse Transcriptase Activities in Mycelial Fungi
- Biology
- 1995
Reverse transcriptases (RT) are RNA-dependent DNA polymerases which were discovered in retroviruses more than 20 years ago and have been designated retroelements mainly on their sequence similarity to retroviral reverse transcriptases.
Towards a reconciliation of the introns early or late views: triosephosphate isomerase genes from insects.
- BiologyBiochimica et biophysica acta
- 1997
On the concept of biological function, junk DNA and the gospels of ENCODE and Graur et al.
- BiologybioRxiv
- 2013
An old hypothesis on the evolution of genome size and on the role of so called ‘junk DNA’ (jDNA), which might explain C-value enigma is brought forward.
Correlation of intron-exon organisation with the three-dimensional structure in glutamate dehydrogenase.
- BiologyBiochimica et biophysica acta
- 1995
Origins and Evolutionary Relationships of Retroviruses
- BiologyThe Quarterly Review of Biology
- 1989
Computer alignment of all these sequences allows an overall phylogeny to be constructed that chronicles the history of events leading to infectious retroviruses.
The signal of ancient introns is obscured by intron density and homolog number
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
This finding matches the expectation of the mixed model of intron origin, in which a fraction of phase zero introns are left from the assembly of the first genes, while other introns have been added in the course of evolution.
An ancient group I intron shared by eubacteria and chloroplasts
- BiologyScience
- 1990
The homology of the intron across chloroplasts and cyanobacteria implies that it was present in their common ancestor and that it has been maintained in their genomes for at least 1 billion years.
References
SHOWING 1-10 OF 17 REFERENCES
Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene.
- Biology, ChemistryProceedings of the National Academy of Sciences of the United States of America
- 1982
An almost complete mRNA sequence has been deduced that predicts a polypeptide having 78% amino acid sequence homology with bovine carboxypeptidase A and there is no evident relationship between the localization of intervening sequences in the gene and functional/structural domains of the protein.
Nucleotide sequence of a Euglena gracilis chloroplast genome region coding for the elongation factor Tu; evidence for a spliced mRNA.
- BiologyNucleic acids research
- 1983
A 1.95 kb transcription product of the Euglena gracilis chloroplast DNA fragment Eco-N + Q is characterized by S1 nuclease analysis and DNA sequencing and it is shown that it is the product of three splicing events.
Chlamydomonas reinhardii gene for the 32 000 mol. wt. protein of photosystem II contains four large introns and is located entirely within the chloroplast inverted repeat
- BiologyThe EMBO journal
- 1984
The chloroplast psbA gene from the green unicellular alga Chlamydomonas reinhardii has been localized, cloned and sequenced. This gene codes for the rapidly‐labeled 32‐kd protein of photosystem II,…
Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox.
- BiologyJournal of cell science
- 1978
Eukaryote DNA can be divided into genic DNA, which codes for proteins (or serves as recognition sites for proteins involved in transcription, replication and recombination), and nucleoskeletal DNA (S-DNA), which exists only because of its nucleoskeleton role in determining the nuclear volume.
Nine introns with conserved boundary sequences in the Euglena gracilis chloroplast ribulose-1,5-bisphosphate carboxylase gene
- BiologyCell
- 1984
Split genes and RNA splicing.
- BiologyScience
- 1979
A number of genes in higher organisms and in their viruses appear to be split. That is, they have "nonsense" stretches of DNA interspersed within the sense DNA. The cell produces a full RNA…
Putative introns in tRNA genes of prokaryotes.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1983
Sequences of two putative tRNA genes, for serine and leucine, from the archaebacterium Sulfolobus solfataricus contain intervening sequences in the anticodon region. Furthermore, the genes lack…
The anticodon of the maize chloroplast gene for tRNAUAALeu is split by a large intron
- Biology
- 1982
The unusual position of the intron in this maize chloroplast tRNA gene suggests a splicing model different from that generally accepted for eukaryotic split tRNA genes.
Chloroplast gene for Mr 32000 polypeptide of photosystem II in Euglena gracilis is interrupted by four introns with conserved boundary sequences.
- BiologyNucleic acids research
- 1984
The gene for the Mr 32000 herbicide binding polypeptide of photosystem II has previously been mapped to the 5 kbp EcoRI fragment Eco I of Euglena gracilis chloroplast DNA. The nucleotide sequence of…