Selfhood, Immunity, and the Biological Imagination: The Thought of Frank Macfarlane Burnet

@article{Crist2000SelfhoodIA,
  title={Selfhood, Immunity, and the Biological Imagination: The Thought of Frank Macfarlane Burnet},
  author={Eileen Crist and Alfred I. Tauber},
  journal={Biology and Philosophy},
  year={2000},
  volume={15},
  pages={509-533}
}
The language of self and nonself has had a prominent place inimmunology. This paper examines Frank Macfarlane Burnet's introductionof the language of selfhood into the science. The distinction betweenself and nonself was an integral part of Burnet's biological outlook– of his interest in the living organism in its totality, itsactivities, and interactions. We show the empirical and conceptualwork of the language of selfhood in the science. The relation betweenself and nonself tied into Burnet's… 
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References

SHOWING 1-10 OF 19 REFERENCES
Postmodernism and immune selfhood.
  • A. Tauber
  • Philosophy, Medicine
    Science in context
  • 1995
TLDR
The bulk of this discussion will focus on how the language and modeling of the science draws from the culture-at-large, and how postmodernists have sought support for their own ideological arguments in immunology.
The immune self: theory or metaphor?
  • A. Tauber
  • Biology, Medicine
    Immunology today
  • 1994
TLDR
Here, Alfred Tauber explores the concept of self and traces the development of the term from Metchnikoff's theory that immunity resides in the active pursuit of identity.
Organism and the Origins of Self
I: Historical Perspectives.- Introduction: Speculations Concerning the Origins of the Self.- Editor's Comments to Lowy.- The Immunological Construction of the Self.- II: The Immune / Cognitive Self.-
The Immunological Construction of the Self
TLDR
It is therefore a prejudice to stress the idea of organism, in the old sense of the word, “as a special kind of life unit, a prejudice which is unbecoming to modern biology” [Gradmann].
Toward an Anthropology of Immunology: The Body as Nation State
In this article I describe the main imagery currently used in popular and scientific descriptions of the immune system in the United States: the body as nation state at war over its external borders,
Immunology Dichotomized. (Book Reviews: Species and Specificity. An Interpretation of the History of Immunology.)
TLDR
This chapter discusses specificity and Unitarianism in XIX Century Botany and Bacteriology, and the decline and persistence of Erlich's chemical theory.
The Dialectical Biologist
TLDR
This chapter discusses Dialectics as a Social Product and the Social Product of Science, the Problem of Lysenkoism, and the Organism as the Subject and Object of Evolution.
Metchnikoff and the Origins of Immunology: From Metaphor to Theory
TLDR
This book discusses Metchnikoff's early embryology, embryological studies after 1872, and current views of phagocyte function.
The Strength of Loose Concepts — Boundary Concepts, Federative Experimental Strategies and Disciplinary Growth: The Case of Immunology
Collaboration between distinct professional groups in producing innovations is at the very heart of modern science, little and Big. In view of what we know of the difficulty of passing information
The Generation of Diversity: Clonal Selection Theory and the Rise of Molecular Immunology
A conceptual orientation the Burnet legacy CST and molecular immunology - a dogmatic alliance interlude - the conventional history germline, somatic mutation and recombinatorial models - 1960-1974
...
1
2
...