Self vs. non-self discrimination during CRISPR RNA-directed immunity

@inproceedings{Marraffini2010SelfVN,
  title={Self vs. non-self discrimination during CRISPR RNA-directed immunity},
  author={Luciano A. Marraffini and Erik J Sontheimer},
  booktitle={Nature},
  year={2010}
}
All immune systems must distinguish self from non-self to repel invaders without inducing autoimmunity. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci protect bacteria and archaea from invasion by phage and plasmid DNA through a genetic interference pathway. CRISPR loci are present in ∼40% and ∼90% of sequenced bacterial and archaeal genomes, respectively, and evolve rapidly, acquiring new spacer sequences to adapt to highly dynamic viral populations. Immunity requires… CONTINUE READING
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