Self-tuning of inhibition by endocannabinoids shapes spike-time precision in CA1 pyramidal neurons.

@article{Dubruc2013SelftuningOI,
  title={Self-tuning of inhibition by endocannabinoids shapes spike-time precision in CA1 pyramidal neurons.},
  author={Franck Dubruc and David Dupret and Olivier Caillard},
  journal={Journal of neurophysiology},
  year={2013},
  volume={110 8},
  pages={1930-44}
}
In the hippocampus, activity-dependent changes of synaptic transmission and spike-timing coordination are thought to mediate information processing for the purpose of memory formation. Here, we investigated the self-tuning of intrinsic excitability and spiking reliability by CA1 hippocampal pyramidal cells via changes of their GABAergic inhibitory inputs and endocannabinoid (eCB) signaling. Firing patterns of CA1 place cells, when replayed in vitro, induced an eCB-dependent transient reduction… CONTINUE READING

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