Self-tolerance to transgenic γδ T cells by intrathymic inactivation

DURING their intrathymic differentiation, T lymphocytes expressing αβ T-cell receptors (TCR) are negatively1–3 and positively selected4–8. This selection contributes to the establishment of self-tolerance and ensures that mature CD4+ and CD8+ cell populations are restricted by the self major histocompatibility complex. Little is known, however, about γδ T… CONTINUE READING