Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model.

@article{Ann2007SelfterminatingAD,
  title={Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model.},
  author={Wim Ann{\'e} and Rik Willems and Patricia Holemans and Frank Beckers and Tania A Roskams and Ilse Lenaerts and Hugo E Ector and Hein Heidb{\"u}chel},
  journal={Journal of molecular and cellular cardiology},
  year={2007},
  volume={43 2},
  pages={
          148-58
        }
}
The development of atrial fibrillation (AF) is associated with electrical and structural remodeling. The aim of this study was to assess the contribution of electrical and structural remodeling to the development of AF in a rapid atrially paced ovine model with and without His bundle ablation and to determine the role of the angiotensin pathway and matrix metalloproteinases in this process. Thirty-five sheep were rapidly paced in the atrium and were randomized to undergo His bundle ablation… CONTINUE READING
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