Self-targeting by CRISPR : gene regulation or autoimmunity ?

  title={Self-targeting by CRISPR : gene regulation or autoimmunity ?},
  author={Xinhong Guo and Konstantin Yu. Popadin and Natalya Markuzon and Yuriy L. Orlov and Yevgenya Kraytsberg and Kim J. Krishnan and G{\'a}bor Zsurka and Douglas M. Turnbull and Wolfram S Kunz and Konstantin Khrapko},
The recently discovered prokaryotic immune system known as CRISPR (clustered regularly interspaced short palindromic repeats) is based on small RNAs (‘spacers’) that restrict phage and plasmid infection. It has been hypothesized that CRISPRs can also regulate self gene expression by utilizing spacers that target self genes. By analyzing CRISPRs from 330 organisms we found that one in every 250 spacers is self-targeting, and that such self-targeting occurs in 18% of all CRISPR-bearing organisms… CONTINUE READING
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