Self-splicing of the Tetrahymena group I ribozyme without conserved base-triples.


BACKGROUND Group I introns share a conserved core region consisting of two domains, P8-P3-P7 and P4-P6, joined by four base-triples. We showed previously that the T4 td intron can perform phosphoester transfer reactions at two splice sites in the absence of both P4-P6 and the conserved base-triples, whereas it is barely able to perform the intact splicing… (More)


  • Presentations referencing similar topics