Self-selection of the analgesic drug carprofen by lame broiler chickens

@article{Danbury2000SelfselectionOT,
  title={Self-selection of the analgesic drug carprofen by lame broiler chickens},
  author={T. C. Danbury and Claire A. Weeks and Avril E. Waterman-Pearson and S. C. Kestin and J P Chambers},
  journal={Veterinary Record},
  year={2000},
  volume={146},
  pages={307 - 311}
}
Lame and sound broilers, selected from commercial flocks, were trained to discriminate between different coloured feeds, one of which contained carprofen. The two feeds were then offered simultaneously and the birds were allowed to select their own diet from the two feeds. In an initial study to assess the most appropriate concentration of drug, the plasma concentrations of carprofen were linearly related to the birds' dietary intake. The walking ability of lame birds was also significantly… Expand
Use of vitamin D to reduce lameness in broilers reared in harsh environments
TLDR
Results suggest that dietary vitamin D is effective in decreasing the severity of lameness by reducing tibial dyschondroplasia and other leg abnormalities of a fast-growing broiler strain reared under harsh conditions. Expand
Treatment of Joint Inflammatory Diseases in the Lame Backyard Chickens with NSAIDs
TLDR
Results of the current study revealed that the meloxicam was the drug of choice with relative safety for treatment of joint inflammatory diseases in chickens. Expand
The behaviour of broiler chickens and its modification by lameness.
TLDR
The alterations of the time budget, in particular the reductions in activities performed whilst standing, and the different feeding strategies adopted, are consistent with lameness imposing a cost on the affected broilers to the detriment of their welfare. Expand
Motor ability and self-selection of an analgesic drug by fast-growing chickens
TLDR
There was an interaction of sex with left-right preference for feeder location, and the hypothesis that broilers with higher gait scores, if experiencing pain, would prefer diets with higher doses of carprofen was rejected. Expand
Toxicological effects of diclofenac in four avian species
TLDR
Investigation of toxico-pathological effects of diclofenac in different avian species found that Severity of clinical disease increased in a dose-related manner and was most severe in broiler chicks, followed by pigeons, Japanese quail, and was least severe in mynah. Expand
THE EFFECT OF DIET SUPPLEMENTATION WITH PROPOLIS ON IMMUNOLOGICAL AND PHYSICOCHEMICAL PROPERTIES OF TIBIA BONES IN BROILER CHICKENS
TLDR
Data showed that the concentration of 500 mg propolis/kg diet did not significantly influence the humoral immune response of broiler against NDV, and the highest haemagglutination inhibiting antibody titer was obtained from birds fed diets supplemented with 125 and 250 mg propoli/ kg diet at 35 days of age. Expand
Study of potential toxic effects of acetylsalicylic acid upon short-term repeated oral administration in chickens
TLDR
It was concluded that acetylsalicylic acid (10 mg/kg) upon repeated oral administration daily for a period of five days found toxic in chickens. Expand
Lame broiler chickens respond to non-steroidal anti-inflammatory drugs with objective changes in gait function: a controlled clinical trial.
TLDR
Evidence was provided that factors besides body conformation influenced mobility in the test cohort, and the model would be useful in future studies to increase the understanding of pain associated with specific lameness types in broiler chickens. Expand
Characterization of growth performance, meat quality and serum biochemical parameters in chickens suffering from tibial dyschondroplasia
TLDR
The TD has adverse effect on the overall growth performance, drumstick parameters, breast meat quality, and some serum biochemical parameters of broilers. Expand
Influence of salicylate administration on weight gain and serum biochemical parameters in broiler chickens
SummaryThe aim of the study was to investigate the effects of different doses of acetylsalicylic acid (ASA) andsodium salicylate (SS) administration on weight gains and serum biochemical parametersExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Effect of carprofen on lameness in broiler chickens
TLDR
Carprofen substantially increased the speed of lame birds, providing evidence that birds with moderate lameness suffer pain when they walk. Expand
Self-selection of ascorbic acid in coloured foods by heat-stressed broiler chicks
TLDR
It is concluded that chicks can learn to associate the colour of the food with its AA content and that they select proportions of supplemented and unsupplemented foods appropriate for their needs, as influenced by environmental temperature. Expand
Comparison of the postoperative analgesic and sedative effects of carprofen and papaveretum in the dog
TLDR
Carprofen provided profound analgesia which was as effective and of longer duration than that produced by papaveretum, and was associated with significantly less postoperative sedation and a quicker return to the normal conscious state. Expand
Pharmacodynamic evaluation of the peripheral pain inhibition by carprofen and flunixin in the horse.
TLDR
Carprofen, flunixin meglumine and placebo in the form of a physiological solution of sodium chloride were tested in an open randomised cross-over trial for analgesic efficacy in horses with two external skin-stimulation systems to find an optimal way to measure pain perception after stimulating the skin with high temperature. Expand
Pharmacodynamics and enantioselective pharmacokinetics of carprofen in the cat.
TLDR
The pharmacodynamics and enantioselective pharmacokinetics of the arylpropionic acid non-steroidal anti-inflammatory drug, carprofen, were investigated in cats after administration of the racemic mixture and it is suggested that a dose of 4.0 mg kg-1 by both intravenous and subcutaneous routes should be evaluated in clinical subjects. Expand
Prevalence of leg weakness in broiler chickens and its relationship with genotype
TLDR
The results indicated that genetic factors were an important cause of leg weakness in broilers and also identified a possible relationship between liveweight and leg weakness. Expand
Self-administration of the analgesic suprofen in arthritic rats: evidence of Mycobacterium butyricum-induced arthritis as an experimental model of chronic pain.
TLDR
The data indicate that relative to normal control the adjuvant arthritis led to a significantly greater intake of a 0.5 mg/ml suprofen solution, and suggest that Mycobacterium butyricum -induced arthritis may offer an experimental model of chronic pain in laboratory animals. Expand
Skeletal disorders in the fowl: a review.
  • B. Thorp
  • Biology, Medicine
  • Avian pathology : journal of the W.V.P.A
  • 1994
TLDR
Bone conditions in poultry can be grouped under three headings based on the age and type of fowls affected, and are indicative of the genetic and production stresses applied to the skeleton. Expand
Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat.
The experiments described here were aimed at further validating adjuvant arthritis as an animal model of chronic pain. It was found that the relative oral intake of a 0.008 mg/ml solution of fentanylExpand
Nonsteroidal anti-inflammatory drugs and corticosteroids for the management of canine osteoarthritis.
TLDR
A review of NSAIDs used in veterinary medicine indicates that relatively little is known regarding their role in treating OA, although controlled studies involving carprofen and etodolac have increased knowledge of the efficacy of specificNSAIDs used for this purpose. Expand
...
1
2
3
...