Self-reported sedation profile of quetiapine extended-release and quetiapine immediate-release during 6-day initial dose escalation in bipolar depression: a multicenter, randomized, double-blind, phase IV study.

@article{Riesenberg2012SelfreportedSP,
  title={Self-reported sedation profile of quetiapine extended-release and quetiapine immediate-release during 6-day initial dose escalation in bipolar depression: a multicenter, randomized, double-blind, phase IV study.},
  author={Robert A. Riesenberg and Irina Baldytcheva and Catherine J. Datto},
  journal={Clinical therapeutics},
  year={2012},
  volume={34 11},
  pages={2202-11}
}
BACKGROUND A human-volunteer study reported lower sedation intensity during escalation of the extended-release formulation of quetiapine fumarate (quetiapine XR) than the immediate-release (IR) formulation. OBJECTIVE To test the hypothesis that the profile of initial tolerability, including sedation, differs between the extended-release (XR) and immediate-release (IR) formulations of quetiapine in patients with bipolar depression. METHODS In a randomized, double-blind, double-dummy… CONTINUE READING
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