Self-repair promotes microtubule rescue

@inproceedings{Aumeier2016SelfrepairPM,
  title={Self-repair promotes microtubule rescue},
  author={Charlotte Aumeier and Laura Schaedel and J{\'e}r{\'e}mie Gaillard and K. P. Ludwig John and Laurent Blanchoin and Manuel Th{\'e}ry},
  booktitle={Nature Cell Biology},
  year={2016}
}
The dynamic instability of microtubules is characterized by slow growth phases stochastically interrupted by rapid depolymerizations called catastrophes. Rescue events can arrest the depolymerization and restore microtubule elongation. However, the origin of these rescue events remains unexplained. Here we show that microtubule lattice self-repair, in structurally damaged sites, is responsible for the rescue of microtubule growth. Tubulin photo-conversion in cells revealed that free tubulin… CONTINUE READING
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