Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

@article{Ensan2016SelfrenewingRA,
  title={Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth},
  author={Sherine Ensan and Angela W-A Li and Rickvinder Besla and Norbert Degousee and Jake Cosme and Mark Roufaiel and Eric Akihiko Shikatani and Mahmoud El-Maklizi and Jesse W Williams and Lauren Robins and Cedric C Li and Bonnie J B Lewis and Tae Jin Yun and Jun Seong Lee and Peter Wieghofer and Ramzi Khattar and Kaveh Farrokhi and John Stephen Byrne and Maral Ouzounian and Caleb C. J. Zavitz and Gary A. Levy and Carla M. T. Bauer and Peter Libby and Mansoor Husain and Filip K Swirski and Cheolho C Cheong and Marco Prinz and Ingo Hilgendorf and Gwendalyn J Randolph and Slava Epelman and Anthony O Gramolini and Myron I Cybulsky and Barry B. Rubin and Clinton S. Robbins},
  journal={Nature Immunology},
  year={2016},
  volume={17},
  pages={159-168}
}
Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute a distinct population among macrophages. Using multiple fate-mapping approaches, we show that arterial macrophages arise embryonically from CX3CR1+ precursors and postnatally from bone marrow–derived monocytes that colonize the tissue immediately after birth. In adulthood… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
62 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

developmental pathways and tissue homeostasis

  • F. Ginhoux, Jung, S. Monocytes, macrophages
  • Nat Rev Immunol 14, 392-404
  • 2014

Similar Papers

Loading similar papers…