Self-renewal vs. differentiation of mouse embryonic stem cells.

  title={Self-renewal vs. differentiation of mouse embryonic stem cells.},
  author={Kathy Sue O'Shea},
  journal={Biology of reproduction},
  volume={71 6},
Embryonic stem (ES) cells are typically derived from the inner cell mass of the preimplantation blastocyst and can both self-renew and differentiate into all the cells and tissues of the embryo. Because they are pluripotent, ES cells have been used extensively to analyze gene function in development via gene targeting. The embryonic stem cell is also an unsurpassed starting material to begin to understand a critical, largely inaccessible period of development. If their differentiation could be… CONTINUE READING
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