Self-referential processing and the prefrontal cortex over the course of depression: a pilot study.

  title={Self-referential processing and the prefrontal cortex over the course of depression: a pilot study.},
  author={C{\'e}dric Lemogne and Helen S. Mayberg and Loretxu Bergouignan and Emmanuelle Volle and Pauline Delaveau and St{\'e}phane Leh{\'e}ricy and J F Allilaire and Philippe Fossati},
  journal={Journal of affective disorders},
  volume={124 1-2},
BACKGROUND Depressed patients exhibit cognitive biases, including maladaptive self-focus. In a previous functional magnetic resonance imaging (fMRI) study, the dorsal medial prefrontal cortex (MPFC) activation during self-referential versus semantic processing was unique to patients, as was the left dorsolateral prefrontal cortex (DLPFC) activation. The aim of this pilot study was to examine whether this pattern was stable over the course of depression. METHODS Sixteen participants (8… CONTINUE READING
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