Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

@article{tefanov2002SelfrecognitionPT,
  title={Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes},
  author={I. {\vS}tefanov{\'a} and J. Dorfman and R. Germain},
  journal={Nature},
  year={2002},
  volume={420},
  pages={429-434}
}
Major histocompatibility complex (MHC) class I and II molecules are highly polymorphic proteins that bind and present foreign peptides to the clonally distributed αβ receptors (TCR) of T lymphocytes. As a population, the immature T lymphocytes generated in the thymus express a very diverse set of TCR specificities. A process of positive selection filters this broad repertoire to optimize peripheral T cells for antigen recognition in the context of available MHC products. Only those precursor T… Expand
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