Self-polarization and directional motility of cytoplasm

@article{Verkhovsky1999SelfpolarizationAD,
  title={Self-polarization and directional motility of cytoplasm},
  author={Alexander B. Verkhovsky and Tatyana M Svitkina and Gary G. Borisy},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={11-S1}
}
BACKGROUND Directional cell motility implies the presence of a steering mechanism and a functional asymmetry between the front and rear of the cell. How this functional asymmetry arises and is maintained during cell locomotion is, however, unclear. Lamellar fragments of fish epidermal keratocytes, which lack nuclei, microtubules and most organelles, present a simplified, perhaps minimal, system for analyzing this problem because they consist of little other than the motile machinery enclosed by… CONTINUE READING
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