Self-perpetuating epigenetic pili switches in bacteria.

  title={Self-perpetuating epigenetic pili switches in bacteria.},
  author={Aaron D. Hernday and Margareta Krabbe and Bruce Albert Braaten and David A. Low},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 Suppl 4},
Bacteria have developed an epigenetic phase variation mechanism to control cell surface pili-adhesin complexes between heritable expression (phase ON) and nonexpression (phase OFF) states. In the pyelonephritis-associated pili (pap) system, global regulators [catabolite gene activator protein (CAP), leucine-responsive regulatory protein (Lrp), DNA adenine methylase (Dam)] and local regulators (PapI and PapB) control phase switching. Lrp binds cooperatively to three pap DNA binding sites, sites… CONTINUE READING