Self-organizing magnetic beads for biomedical applications

  title={Self-organizing magnetic beads for biomedical applications},
  author={Markus Gusenbauer and Alexander Kovacs and Franz Reichel and Lukas Exl and Simon Bance and Harald Oezelt and Thomas Schrefl},

A tunable cancer cell filter using magnetic beads: cellular and fluid dynamic simulations

A simulation tool is developed that combines micromagnetics, discrete particle dynamics and fluid dynamics, in order to design micropost arrays made of interacting beads to isolate circulating tumor cells using lab-on-chip technologies.

Magnetically actuated circular displacement micropump

The development process of a magnetically actuated displacement micropump is demonstrated. Two permanent magnets are driven by electromagnets in a circular housing. The magnetic plugs dynamically act


For the proper simulation of processes inside microfluidic devices, proper model for blood flow must be used. We use the lattice-Boltzmann method for the blood plasma flow and the immersed boundary

Ferromagnetic beads sedimentation forced by an external magnetic field

This document reports the work I did under the supervision of Mickaël Bourgoin and Valérie Vidal at the Laboratoire de Physique at the ENS de Lyon. The topic deals with the sedimentation of

Hydrodynamics of Highly Viscous Flow past a Compound Particle: Analytical Solution

To investigate the translation of a compound particle in a highly viscous, incompressible fluid, we carry out an analytic study on flow past a fixed spherical compound particle. The spherical object

Mesh-Based Modeling of Individual Cells and Their Dynamics in Biological Fluids

This text is focused on mesh-based model and on its capabilities to cover complex mechano-elastic properties combined with adhesion and magnetic phenomena.

Scalability of forces in mesh-based models of elastic objects

This work discusses which elastic forces in this model are scalable, which are not and demonstrates that mesh differences and characteristics of simulation experiments have to be taken into account when calibrating elastic coefficients.

Fractional differential equation modeling of viscoelastic fluid in mass-spring-magnetorheological damper mechanical system

The mass-spring-damper system has the minimum complexity scenario which characterizes almost all the mechanical vibration phenomena. Also it is well known that a second-order differential equation



Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays

Ephesia provides a powerful approach to cell capture and typing allowing fully automated high resolution and quantitative immunophenotyping and morphological analysis, and requires at least 10 times smaller sample volume and cell numbers than cytometry, potentially increasing the range of indications and the success rate of microbiopsy-based diagnosis and reducing analysis time and cost.

Dynamics of rotating paramagnetic particle chains simulated by particle dynamics, Stokesian dynamics and lattice Boltzmann methods

Paramagnetic particles, when subjected to external unidirectional rotating magnetic fields, form chains which rotate along with the magnetic field. In this paper three simulation methods, particle

3D analytical calculation of the forces exerted between two cuboidal magnets

The interaction forces exerted between permanent magnets are used in many magneto-mechanical devices (magnetic bearings, couplings, etc...). By analytical calculation, 2D problems can be solved

Parylene membrane slot filter for the capture, analysis and culture of viable circulating tumor cells

This paper presents a method of capturing viable circulating tumor cells (CTC) from human whole blood using constant-pressure-driven filtration through a specially designed parylene-C membrane “slot”

Permanent Magnet and Electromechanical Devices: Materials, Analysis, and Applications

Preface 1. Materials Introduction Units Classification of Materials Atomic Magnetic Moments Single electron atoms Multielectron atoms Paramagnetism Ferromagnetism Magnetostatic Energy Demagnetization

Isolation of rare circulating tumour cells in cancer patients by microchip technology

The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.

Affinity and size capture of circulating tumor cells: A platform for increased sensitivity

The MA3 microfluidic chip captures CTCs using a combination of affinity and size filtration, which may allow for more efficient capture than affinity alone and further work evaluating this platform in late-stage breast cancer patients is ongoing.

Theoretical study of nonlinear transition shift in double-layer perpendicular media

Nonlinear transition shift (NLTS) in perpendicular media is studied theoretically. From an analytic expression for demagnetizing field in perpendicular media, the difference between transition shift