Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.

  title={Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.},
  author={S. Lakshmi Kusuma and Yu-I Shen and Donny Hanjaya-Putra and Prashant Mali and Linzhao Cheng and Sharon Gerecht},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 31},
The success of tissue regenerative therapies is contingent on functional and multicellular vasculature within the redeveloping tissue. Although endothelial cells (ECs), which compose the vasculature's inner lining, are intrinsically able to form nascent networks, these structures regress without the recruitment of pericytes, supporting cells that surround microvessel endothelium. Reconstruction of typical in vivo microvascular architecture traditionally has been done using distinct cell sources… CONTINUE READING
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Comparative Sequencing Program (2012) Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression

  • L Cheng, NISC
  • Cell Stem Cell 10(3):337–344
  • 2012
Highly Influential
14 Excerpts

Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix. Blood 118(3):804–815

  • D Hanjaya-Putra
  • 2011
Highly Influential
6 Excerpts

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