Self-organization of the phosphatidylinositol lipids signaling system for random cell migration.

@article{Arai2010SelforganizationOT,
  title={Self-organization of the phosphatidylinositol lipids signaling system for random cell migration.},
  author={Yoshiyuki Arai and Tatsuo Shibata and Satomi Matsuoka and Masayuki J. Sato and Toshio Yanagida and Masahiro Ueda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 27},
  pages={12399-404}
}
Phosphatidylinositol (PtdIns) lipids have been identified as key signaling mediators for random cell migration as well as chemoattractant-induced directional migration. However, how the PtdIns lipids are organized spatiotemporally to regulate cellular motility and polarity remains to be clarified. Here, we found that self-organized waves of PtdIns 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] are generated spontaneously on the membrane of Dictyostelium cells in the absence of a chemoattractant… CONTINUE READING
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Self-organization in cell biology: a brief history

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