Self-organization of the in vitro attached human embryo

@article{Deglincerti2016SelforganizationOT,
  title={Self-organization of the in vitro attached human embryo},
  author={Alessia Deglincerti and Gist F. Croft and Lauren N. Pietila and Magdalena Zernicka-Goetz and Eric D. Siggia and Ali H. Brivanlou},
  journal={Nature},
  year={2016},
  volume={533},
  pages={251-254}
}
Implantation of the blastocyst is a developmental milestone in mammalian embryonic development. At this time, a coordinated program of lineage diversification, cell-fate specification, and morphogenetic movements establishes the generation of extra-embryonic tissues and the embryo proper, and determines the conditions for successful pregnancy and gastrulation. Despite its basic and clinical importance, this process remains mysterious in humans. Here we report the use of a novel in vitro system… CONTINUE READING
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