Self-organization of rat cardiac cells into contractile 3-D cardiac tissue.

@article{Baar2004SelforganizationOR,
  title={Self-organization of rat cardiac cells into contractile 3-D cardiac tissue.},
  author={Keith Baar and Ravi K. Birla and Marvin Oliverio Boluyt and Gregory H. Borschel and Ellen M. Arruda and Robert Anthony Gamboa Dennis},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={19 2},
  pages={
          275-7
        }
}
The mammalian heart is not known to regenerate following injury. Therefore, there is great interest in developing viable tissue-based models for cardiac assist. Recent years have brought numerous advances in the development of scaffold-based models of cardiac tissue, but a self-organizing model has yet to be described. Here, we report the development of an in vitro cardiac tissue without scaffolding materials in the contractile region. Using an optimal concentration of the adhesion molecule… CONTINUE READING
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