Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells

@article{Reilein2005SelforganizationOA,
  title={Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells},
  author={Amy R. Reilein and Soichiro Yamada and W. James Nelson},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={171},
  pages={845 - 855}
}
Mechanisms underlying the organization of centrosome-derived microtubule arrays are well understood, but less is known about how acentrosomal microtubule networks are formed. The basal cortex of polarized epithelial cells contains a microtubule network of mixed polarity. We examined how this network is organized by imaging microtubule dynamics in acentrosomal basal cytoplasts derived from these cells. We show that the steady-state microtubule network appears to form by a combination of… CONTINUE READING
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