Self-organization of Hebbian Synapses in Hippocampal Neurons

  title={Self-organization of Hebbian Synapses in Hippocampal Neurons},
  author={Thomas H. Brown and Zachary F. Mainen and Anthony M. Zador and Brenda J. Claiborne},
We are exploring the significance of biological complexity for neuronal computation. Here we demonstrate that Hebbian synapses in realistically-modeled hippocampal pyramidal cells may give rise to two novel forms of self -organization in response to structured synaptic input. First, on the basis of the electrotonic relationships between synaptic contacts, a cell may become tuned to a small subset of its input space. Second, the same mechanisms may produce clusters of potentiated synapses across… CONTINUE READING


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