Self-nonself discrimination and tolerance in T and B lymphocytes

@article{Miller1993SelfnonselfDA,
  title={Self-nonself discrimination and tolerance in T and B lymphocytes},
  author={J. F. Miller},
  journal={Immunologic Research},
  year={1993},
  volume={12},
  pages={115-130}
}
  • J. Miller
  • Published 1993
  • Biology
  • Immunologic Research
The immune system must not only fight off infections, but also ensure that it does not react against its own body tissues. Since clones of lymphocytes have predetermined reactivities, some will be self-reactive and have the potential to cause damage. They should therefore be neutralized in some way. In a system as complex and important as that governing self-tolerance, many mechanisms must exist to neutralize autoaggressive lymphocytes. They may be classified under two main groups. In one the… 
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19 Citations
Background Citations
6

19 Citations

The immune system victorious: Selective preservation of self
TLDR
Investigations elucidating the role of T cell receptors, MHC molecules and antigen peptides in self-nonself discrimination are discussed, and a introductory summary of the remaining articles in the issue that address selected topics inSelf-non self discrimination.
Presence in peripheral blood of healthy individuals of autoreactive T cells to a membrane antigen present on bone marrow-derived cells.
Human self‐protein CD8+ T‐cell epitopes are both positively and negatively selected
TLDR
It is shown that there is a clear selection for the presentation of specific self‐protein types, and that this selection can be directly observed through the fraction of non‐synonymous SNP (replacement fraction), which is significantly higher inside epitopes than outside.
BIOLOGICAL SHIELD TO AVOID DEFILEMENTS AND DISEASES: IMMUNITY: AN OVERVIEW
TLDR
Immunity can be defined as the ability to withstand against diseases, the state of having sufficient biological shield to avoid defilements and diseases or other unwanted biological invasion.
Crucial Role of Tissue-specific Apoptosis on the Development of Primary Sjögren's Syndrome
Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination.
TLDR
RNA-associated motifs produced during viral infection bridge the early response with the late adaptive phase, regulating the activation and differentiation of antigen-specific B and T cells, in addition to a short-term impact on innate immunity.
Regulation of T lymphocyte subsets.
TLDR
Using murine T cells which express a transgenic, antigen-specific alpha/beta T cell receptor (TCR) specific for L(d) class I major histocompatibility complex antigen, it is found that CD8+ lymphocytes can be divided into functional subsets.
Influence of graft versus host reaction on the T cell repertoire differentiating from bone marrow precursors following allogeneic bone marrow transplantation.
Role of phytochemicals as immunomodulatory agents: A review
TLDR
The present review focused on the immune-modulating activity of various phytochemicals such as alkaloids, polysaccharides, lectins, glycosides, phenolic compounds, flavonoids, anthocyanins, tannins, saponins, terpenoids, sterols and also explains the role of antioxidants as immune- modulators.
In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes
TLDR
Direct in vivo evidence for the diabetogenic effect of this human MHC class II molecule is provided and a unique “humanized” animal model of spontaneous diabetes is provided.
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