Self-nonself discrimination and tolerance in T and B lymphocytes

@article{Miller1993SelfnonselfDA,
  title={Self-nonself discrimination and tolerance in T and B lymphocytes},
  author={J. F. Miller},
  journal={Immunologic Research},
  year={1993},
  volume={12},
  pages={115-130}
}
  • J. Miller
  • Published 1993
  • Biology
  • Immunologic Research
The immune system must not only fight off infections, but also ensure that it does not react against its own body tissues. Since clones of lymphocytes have predetermined reactivities, some will be self-reactive and have the potential to cause damage. They should therefore be neutralized in some way. In a system as complex and important as that governing self-tolerance, many mechanisms must exist to neutralize autoaggressive lymphocytes. They may be classified under two main groups. In one the… 
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