Self-nonself discrimination and tolerance in T and B lymphocytes

  title={Self-nonself discrimination and tolerance in T and B lymphocytes},
  author={J. F. Miller},
  journal={Immunologic Research},
  • J. Miller
  • Published 1993
  • Biology
  • Immunologic Research
The immune system must not only fight off infections, but also ensure that it does not react against its own body tissues. Since clones of lymphocytes have predetermined reactivities, some will be self-reactive and have the potential to cause damage. They should therefore be neutralized in some way. In a system as complex and important as that governing self-tolerance, many mechanisms must exist to neutralize autoaggressive lymphocytes. They may be classified under two main groups. In one the… 
The immune system victorious: Selective preservation of self
Investigations elucidating the role of T cell receptors, MHC molecules and antigen peptides in self-nonself discrimination are discussed, and a introductory summary of the remaining articles in the issue that address selected topics inSelf-non self discrimination.
Human self‐protein CD8+ T‐cell epitopes are both positively and negatively selected
It is shown that there is a clear selection for the presentation of specific self‐protein types, and that this selection can be directly observed through the fraction of non‐synonymous SNP (replacement fraction), which is significantly higher inside epitopes than outside.
Immunity can be defined as the ability to withstand against diseases, the state of having sufficient biological shield to avoid defilements and diseases or other unwanted biological invasion.
Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination.
RNA-associated motifs produced during viral infection bridge the early response with the late adaptive phase, regulating the activation and differentiation of antigen-specific B and T cells, in addition to a short-term impact on innate immunity.
Regulation of T lymphocyte subsets.
Using murine T cells which express a transgenic, antigen-specific alpha/beta T cell receptor (TCR) specific for L(d) class I major histocompatibility complex antigen, it is found that CD8+ lymphocytes can be divided into functional subsets.
Role of phytochemicals as immunomodulatory agents: A review
The present review focused on the immune-modulating activity of various phytochemicals such as alkaloids, polysaccharides, lectins, glycosides, phenolic compounds, flavonoids, anthocyanins, tannins, saponins, terpenoids, sterols and also explains the role of antioxidants as immune- modulators.
In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes
Direct in vivo evidence for the diabetogenic effect of this human MHC class II molecule is provided and a unique “humanized” animal model of spontaneous diabetes is provided.


Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies
The immune system maintains a constant capability to respond to the outside world while remaining unresponsive to self. There may be two broad explanations for self-tolerance. First there must be
Cellular mechanisms of immunologic tolerance.
  • G. Nossal
  • Biology
    Annual review of immunology
  • 1983
It is a matter of considerable difficulty to judge whether the effects observed mimic the physiological situation of lymphocytes coming to grips with the need to avoid horror aulotoxicus, or whether the model illustrates some facet of immunoregulation needed to limit the cascade of immunoproliferation that follows the introduction of antigen.
The Florey Lecture, 1989 - Self-tolerance: the key to autoimmunity
  • A. Basten
  • Biology
    Proceedings of the Royal Society of London. B. Biological Sciences
  • 1989
'Horor autotoxicus', as it was termed by Erhlich, is a rare clinical event despite the genetic potential of every individual to mount immune responses to self-antigens, and different mechanisms of tolerance induction operate for self-reactive T lymphocytes compared with B lymphocytes.
Suppressor T-cell memory
The experiments reported here demonstrate the presence of specific long lived memory Ts cells in mice exposed to the protein antigen, human γ-globulin (HGG), and the potential value of Ts in the maintenance of active tolerance to self antigens would be enhanced if a pool of memory cells existed which could be rapidly recruited to abort incipient autoimmune responses.
Tolerance of class I histocompatibility antigens expressed extrathymically
The results point to an extrathymic mechanism of tolerance induction, dependent on the continuous presence of antigen and the lack of IL-2 in the local environment of potentially reactive T cells, in older, diabetic mice.
T‐Cell Tolerance in Transgenic Mice Expressing Major Histocompatibility Class I Molecules in Defined Tissues
A fundamental question in immunology is concerned with the mechanism by which tolerance to self components is imparted to developing lymphocytes. This issue is especially relevant to T lymphocytes
The need for central and peripheral tolerance in the B cell repertoire.
The immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells, but the possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models.
Identity of cells that imprint H–2-restricted T-cell specificity in the thymus
Evidence is presented here that dGuo-treated thymus grafts do imprint T cells with H–2-restricted specificity for antigen, suggesting that induction of tolerance and H-2 restriction are controlled by different cells in the thymu.
Do Suppressor T Cells Exist?
  • G. Möller
  • Biology, Medicine
    Scandinavian journal of immunology
  • 1988
The plausibility of the notion that there is a separate T cell subpopulation with a suppressor function, which exists to control other cells of the immune system is questioned, but the notion of suppressor Tcells as a separate subpopulation of T cells is sceptical.
Positive and negative selection of an antigen receptor on T cells in transgenic mice
In the periphery of transgenic mice expressing Ld, functional T cells bearing the 2C T-cell receptor were deleted and this elimination of autoreactive T cells appears to take place at or before the CD4+CD8+ stage in thymocyte development.