Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, in vitro and in vivo evaluation.

@article{Khan2015SelfnanoemulsifyingDD,
  title={Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, in vitro and in vivo evaluation.},
  author={Abdul Wadood Khan and Sabna Kotta and Shahid Husain Ansari and Rakesh Kumar Sharma and Javed Ali},
  journal={Drug delivery},
  year={2015},
  volume={22 4},
  pages={552-61}
}
Naringenin (NRG), predominant flavanone in grapefruits, possesses anti-inflammatory, anti-carcinogenic, hepato-protective and anti-lipid peroxidation effects. Slow dissolution after oral ingestion due to its poor solubility in water, as well as low bioavailability following oral administration, restricts its therapeutic application. The study is an attempt to improve the solubility and bioavailability of NRG by employing self-nanoemulsifying drug delivery technique. Preliminary screening was… CONTINUE READING
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