Self-injurious behaviour: a comparison of caffeine and pemoline models in rats

@article{Kies2004SelfinjuriousBA,
  title={Self-injurious behaviour: a comparison of caffeine and pemoline models in rats},
  author={Staci Denise Kies and D P Devine},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={79},
  pages={587-598}
}
  • S. D. Kies, D. Devine
  • Published 1 December 2004
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
Self-injurious behaviour (SIB) is a debilitating behaviour disorder that can have life-threatening consequences. It is often exhibited in intellectually handicapped and autistic populations, and it has been modeled with pharmacological manipulations in animals. We have characterized the induction of SIB using high doses of caffeine and pemoline in rats. Caffeine only produced very mild SIB in a small proportion of the rats, when administered repeatedly at very high doses (140-185 mg/kg/day… 
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Highly Influential Citations
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Background Citations
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Self-injurious behaviour: limbic dysregulation and stress effects in an animal model.
TLDR
A broad sampling of regional metabolic activity indicates that the pemoline regimen produces enduring changes that are localised to specific limbic, hypothalamic and striatal structures, and the potential role of limbic function in aetiology of SIB is supported by the finding that p emoline-induced self-injury is exacerbated by prior exposure to social defeat stress.
Self-Injurious Behavior: Investigating Individual Differences in an Animal Model
Self-injurious behavior (SIB) is a devastating disorder that consists of deliberate acts of self-inflicted tissue damage commonly exhibited by individuals with developmental disabilities, autism, and…
Individual differences in vulnerability for self-injurious behavior: Studies using an animal model
TLDR
Vulnerability to develop pemoline-induced SIB is positively correlated with, and can be predicted based upon, a behavioral measure of innate stress responsiveness, and characteristics that are common in developmental disorders may help predispose afflicted individuals to self-injure.
Nifedipine Suppresses Self-Injurious Behaviors in Animals
TLDR
The results suggest that nifedipine may target a common biological mechanism in the expression of self-injurious behavior, and they suggest it should be considered in the treatment ofSelf-injury in humans.
Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour
TLDR
It is suggested that repeated pemoline administration induces glutamate-mediated neuroplastic changes that lead to the eventual expression of SIB.
The role of anxiety in vulnerability for self-injurious behaviour: studies in a rodent model
TLDR
Investigating potential interactions between anxiety and self-injury in a rat model of pemoline-induced self-biting suggests that anxiety may contribute to the etiology and/or expression of self- injurious behaviour, and indicates that further research is warranted.
Chapter 6 Animal Models of Self‐Injurious Behavior: Induction, Prevention, and Recovery
Abstract The purpose of this review is to organize the literature over the past 50 years on animal models for self‐injurious behavior (SIB). Of the many animal models for SIB, there are four models…
The Pemoline Model of Self-Injurious Behavior: An Update.
  • D. Devine
  • Medicine, Psychology
    Methods in molecular biology
  • 2019
TLDR
A focus on one or more specific behavioral characteristics that occur in multiple neurodevelopmental disorders (e.g., self-injury) may be a fruitful strategy and the development of these behaviorally focused models may yield increased understanding of the endogenous and environmental factors that confer vulnerability for aberrant behaviors.
The pemoline model of self-injurious behaviour.
  • D. Devine
  • Psychology, Medicine
    Methods in molecular biology
  • 2012
TLDR
Development of behaviourally focused models yields increased understanding of the genetic basis and biochemical abnormalities that underlie specific psychiatric dysfunctions, which improve translational power and help to identify targets for effective pharmacotherapies.
Animal models of self-injurious behaviour: an overview.
  • D. Devine
  • Biology, Medicine
    Methods in molecular biology
  • 2012
TLDR
Convergent evidence from clinical pharmacotherapy, brain imaging studies, postmortem neurochemical analyses, and animal models indicates that dopaminergic insufficiency is a key culprit in self-injury.
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