Self-injurious behaviour: a comparison of caffeine and pemoline models in rats

@article{Kies2004SelfinjuriousBA,
  title={Self-injurious behaviour: a comparison of caffeine and pemoline models in rats},
  author={S. D. Kies and D. Devine},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={79},
  pages={587-598}
}
  • S. D. Kies, D. Devine
  • Published 2004
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
    • Self-injurious behaviour (SIB) is a debilitating behaviour disorder that can have life-threatening consequences. It is often exhibited in intellectually handicapped and autistic populations, and it has been modeled with pharmacological manipulations in animals. We have characterized the induction of SIB using high doses of caffeine and pemoline in rats. Caffeine only produced very mild SIB in a small proportion of the rats, when administered repeatedly at very high doses (140-185 mg/kg/day… CONTINUE READING
    View on Elsevier
    doi.org
    26 Citations
    Highly Influencial Citations
    2
    Background Citations
    11
    Methods Citations
    5
    Results Citations
    2
    26 Citations
    Citation Type

    Citation Type

    Self-injurious behaviour: limbic dysregulation and stress effects in an animal model.
    • 13
    • PDF
    Self-Injurious Behavior: Investigating Individual Differences in an Animal Model
    • PDF
    Individual differences in vulnerability for self-injurious behavior: Studies using an animal model
    • 21
    Nifedipine Suppresses Self-Injurious Behaviors in Animals
    • 21
    Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour
    • 18
    The role of anxiety in vulnerability for self-injurious behaviour: studies in a rodent model
    • 12
    • PDF
    Chapter 6 Animal Models of Self‐Injurious Behavior: Induction, Prevention, and Recovery
    • 7
    The Pemoline Model of Self-Injurious Behavior: An Update.
    • D. P. Devine
    • Psychology, Medicine
    • Methods in molecular biology
    • 2019
    The pemoline model of self-injurious behaviour.
    • D. P. Devine
    • Psychology, Medicine
    • Methods in molecular biology
    • 2012
    • 5
    Animal models of self-injurious behaviour: an overview.
    • D. P. Devine
    • Biology, Medicine
    • Methods in molecular biology
    • 2012
    • 17

    References

    SHOWING 1-10 OF 76 REFERENCES
    Repeated pemoline produces self-injurious behavior in adult and weanling rats
    • 25
    Paradoxical Effects of Serotonin and Opioids in Pemoline-Induced Self-Injurious Behavior
    • 19
    Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine
    • 63
    Cortical Damage Enhances Pemoline-Induced Self-Injurious Behavior in Prepubertal Rats
    • 26
    Low-dose naltrexone inhibits pemoline-induced self-biting behavior in prepubertal rats.
    • 20
    Clonidine potentiates drug induced self-injurious behavior in rats
    • 26
    Pharmacologic control of pemoline induced self-injurious behavior in rats
    • 61
    Investigations of Amitraz Neurotoxicity in Rats IV. Assessment of Toxicity Syndrome Using a Functional Observational Battery
    • 22
    Self‐injurious behavior in rhesus monkeys: New insights into its etiology, physiology, and treatment
    • M. Novak
    • Medicine
    • American journal of primatology
    • 2003
    • 178
    Pretreatment with MK-801 inhibits pemoline-induced self-biting behavior in prepubertal rats.
    • 30