Self-injurious behaviour: a comparison of caffeine and pemoline models in rats

@article{Kies2004SelfinjuriousBA,
  title={Self-injurious behaviour: a comparison of caffeine and pemoline models in rats},
  author={Staci Denise Kies and D P Devine},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={79},
  pages={587-598}
}
  • S. D. Kies, D. Devine
  • Published 1 December 2004
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
Self-injurious behaviour (SIB) is a debilitating behaviour disorder that can have life-threatening consequences. It is often exhibited in intellectually handicapped and autistic populations, and it has been modeled with pharmacological manipulations in animals. We have characterized the induction of SIB using high doses of caffeine and pemoline in rats. Caffeine only produced very mild SIB in a small proportion of the rats, when administered repeatedly at very high doses (140-185 mg/kg/day… 
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  • D. Devine
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    Methods in molecular biology
  • 2019
TLDR
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The pemoline model of self-injurious behaviour.
  • D. Devine
  • Psychology, Medicine
    Methods in molecular biology
  • 2012
TLDR
Development of behaviourally focused models yields increased understanding of the genetic basis and biochemical abnormalities that underlie specific psychiatric dysfunctions, which improve translational power and help to identify targets for effective pharmacotherapies.
Animal models of self-injurious behaviour: an overview.
  • D. Devine
  • Biology, Medicine
    Methods in molecular biology
  • 2012
TLDR
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