Self-injurious behaviour: a comparison of caffeine and pemoline models in rats

@article{Kies2004SelfinjuriousBA,
  title={Self-injurious behaviour: a comparison of caffeine and pemoline models in rats},
  author={S. D. Kies and D. Devine},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={79},
  pages={587-598}
}
  • S. D. Kies, D. Devine
  • Published 2004
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • Self-injurious behaviour (SIB) is a debilitating behaviour disorder that can have life-threatening consequences. It is often exhibited in intellectually handicapped and autistic populations, and it has been modeled with pharmacological manipulations in animals. We have characterized the induction of SIB using high doses of caffeine and pemoline in rats. Caffeine only produced very mild SIB in a small proportion of the rats, when administered repeatedly at very high doses (140-185 mg/kg/day… CONTINUE READING
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